Showing Compound 5-Isopropyl-2-methylphenol (FDB014512)

Record Information

Version

1.0

Creation date

2010-04-08 22:11:19 UTC

Update date

2020-09-17 15:30:27 UTC

Primary ID

FDB014512

Secondary Accession Numbers

Not Available

Chemical Information

FooDB Name

5-Isopropyl-2-methylphenol

Description

Carvacrol or 5-isopropyl-2-methylphenol is a naturally occurring organic compound classified as an alkylphenol (containing at least one aromatic ring) although biochemically, it is a monoterpenoid synthesized from isoprene units. Carvacrol is an isoprenoid lipid molecule that is very hydrophobic, practically insoluble in water, and relatively neutral. Carvacrol has a camphor, spice, and thymol taste with a characteristic pungent, warm odor of oregano. Carvacrol is found in highest concentrations in pot marjorams, common thymes, and black walnuts and in lower concentrations in rosemaries, common oregano, and sweet marjorams. Carvacrol was detected in pepper (spice), tamarinds, peppermints, lovages, and sweet basils making carvacrol a potential biomarker for the consumption of these foods. It has been added as a flavoring agent, preservative and fragrance in products. Its bioactivity and toxicological properties have been reviewed (PMID: 24915411). As a constituent of many essential oils, carvocrol was demonstrated to have anti-biofilm and anti-microbial properties (PMID: 30067078) and acts as an anti-viral against the norovirus (PMID: 24779581).

CAS Number

499-75-2

Structure

MOL SDF PDB SMILES InChI

Synonyms

Synonym	Source
1-Hydroxy-2-methyl-5-isopropylbenzene	ChEBI
1-Methyl-2-hydroxy-4-isopropylbenzene	ChEBI
2-Hydroxy-p-cymene	ChEBI
2-Methyl-5-(1-methylethyl)phenol	ChEBI
2-Methyl-5-isopropylphenol	ChEBI
2-p-Cymenol	ChEBI
3-Isopropyl-6-methylphenol	ChEBI
5-Isopropyl-O-cresol	ChEBI
2-Hydroxy-4-isopropyl-1-methylbenzene	HMDB
2-Hydroxycymene	HMDB
2-Methyl-5-(1-methylethyl)-phenol	HMDB
3-Isopropyl-6-methyl-phenol	HMDB
5-Isopropyl-2-methyl-phenol	HMDB
6-Methyl-3-isopropylphenol	HMDB
Antioxine	HMDB
BENZENE,2-hydroxy,4-isopropyl,1-methyl carvacrol	HMDB
Carvacrol	HMDB
Cymenol	HMDB
Cymophenol	HMDB
FEMA 2245	HMDB
Hydroxy-P-cymene	HMDB
Isopropyl-O-cresol	HMDB
Isothymol	HMDB
Isothymol (=2-isopropyl-4-methyl phenol)	HMDB
Karvakrol	HMDB
Methyl-5-(1-methylethyl)phenol	HMDB
O-Thymol	HMDB
Oxycymol	HMDB
P-Cymen-2-ol	HMDB
P-Cymene-2-ol	HMDB
P-Mentha-1,3,5-trien-2-ol	HMDB
5-Isopropyl-2-methylphenol	ChEBI
5-Isopropyl-o-cresol	db_source
6-methyl-3-isopropylphenol	biospider
BENZENE,2-HYDROXY,4-ISOPROPYL,1-METHYL CARVACROL	biospider
Cymene-2-ol, p-	biospider
Hydroxy-p-cymene	biospider
Isopropyl-o-cresol	biospider
Isothymol (=2-Isopropyl-4-methyl phenol)	biospider
o-Cresol, 5-isopropyl-	biospider
O-thymol	biospider
p-Cymen-2-ol	db_source
p-Cymene, 2-hydroxy-	biospider
p-Mentha-1,3,5-trien-2-ol	db_source
Phenol, 2-methyl-5-(1-methylethyl)-	biospider
Phenol, 3-isopropyl-6-methyl-	biospider
Phenol, 5-isopropyl-2-methyl-	biospider

Predicted Properties

Property	Value	Source
Water Solubility	0.47 g/L	ALOGPS
logP	3.2	ALOGPS
logP	3.43	ChemAxon
logS	-2.5	ALOGPS
pKa (Strongest Acidic)	10.42	ChemAxon
pKa (Strongest Basic)	-5.5	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	1	ChemAxon
Hydrogen Donor Count	1	ChemAxon
Polar Surface Area	20.23 Å²	ChemAxon
Rotatable Bond Count	1	ChemAxon
Refractivity	47.27 m³·mol⁻¹	ChemAxon
Polarizability	17.88 Å³	ChemAxon
Number of Rings	1	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	Yes	ChemAxon
MDDR-like Rule	No	ChemAxon

Chemical Formula

C10H14O

IUPAC name

2-methyl-5-(propan-2-yl)phenol

InChI Identifier

InChI=1S/C10H14O/c1-7(2)9-5-4-8(3)10(11)6-9/h4-7,11H,1-3H3

InChI Key

RECUKUPTGUEGMW-UHFFFAOYSA-N

Isomeric SMILES

CC(C)C1=CC(O)=C(C)C=C1

Average Molecular Weight

150.221

Monoisotopic Molecular Weight

150.104465071

Classification

Description

Belongs to the class of organic compounds known as aromatic monoterpenoids. These are monoterpenoids containing at least one aromatic ring.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Prenol lipids

Sub Class

Monoterpenoids

Direct Parent

Aromatic monoterpenoids

Alternative Parents

Substituents

P-cymene
Aromatic monoterpenoid
Monocyclic monoterpenoid
Cumene
Phenylpropane
O-cresol
1-hydroxy-4-unsubstituted benzenoid
1-hydroxy-2-unsubstituted benzenoid
Phenol
Toluene
Benzenoid
Monocyclic benzene moiety
Hydrocarbon derivative
Organic oxygen compound
Organooxygen compound
Aromatic homomonocyclic compound

Molecular Framework

Aromatic homomonocyclic compounds

External Descriptors

phenols (CHEBI:3440 )
p-menthane monoterpenoid (CHEBI:3440 )
botanical anti-fungal agent (CHEBI:3440 )
Menthane monoterpenoids (C09840 )
Cyclic monoterpenes (C09840 )
Menthane monoterpenoids (LMPR0102090017 )

Ontology

Disposition

Route of exposure:

Enteral:

Ingestion

Source:

Biological:

Animal

Plant:

Poaceae

Biological location:

Cell and elements:

Extracellular

Subcellular:

Biofluid and excreta:

Process

Naturally occurring process:

Biological process:

Biochemical process:

Chemical reaction:

Lipid peroxidation

Biochemical pathway:

Lipid metabolism pathway

Cellular process:

Cell signaling

Role

Industrial application:

Food and nutrition:

Flavoring agent

Biological role:

Physico-Chemical Properties - Experimental

Property	Value	Reference
Physical state	Liquid
Physical Description	Not Available
Mass Composition	C 79.96%; H 9.39%; O 10.65%	DFC
Melting Point	Mp 3.5°	DFC
Boiling Point	Bp10 113°	DFC
Experimental Water Solubility	1.25 mg/mL at 25 oC	YALKOWSKY,SH & DANNENFELSER,RM (1992)
Experimental logP	3.49	GRIFFIN,S ET AL. (1999)
Experimental pKa	Not Available
Isoelectric point	Not Available
Charge	Not Available
Optical Rotation	Not Available
Spectroscopic UV Data	Not Available
Density	Not Available
Refractive Index	Not Available

Spectra

EI-MS/GC-MS

Type	Description	Splash Key	View
EI-MS	Mass Spectrum (Electron Ionization)	splash10-000i-3900000000-33df3527bcfd42c1888b	Spectrum
GC-MS	5-Isopropyl-2-methylphenol, non-derivatized, GC-MS Spectrum	splash10-000i-1900000000-ef32f1d484b3c21ba134	Spectrum
GC-MS	5-Isopropyl-2-methylphenol, non-derivatized, GC-MS Spectrum	splash10-000i-0900000000-b0006c01682dd3cd5032	Spectrum
GC-MS	5-Isopropyl-2-methylphenol, non-derivatized, GC-MS Spectrum	splash10-000i-6900000000-b77d2bc899f0364b95e6	Spectrum
GC-MS	5-Isopropyl-2-methylphenol, non-derivatized, GC-MS Spectrum	splash10-000i-1900000000-ef32f1d484b3c21ba134	Spectrum
GC-MS	5-Isopropyl-2-methylphenol, non-derivatized, GC-MS Spectrum	splash10-000i-0900000000-b0006c01682dd3cd5032	Spectrum
GC-MS	5-Isopropyl-2-methylphenol, non-derivatized, GC-MS Spectrum	splash10-000i-6900000000-b77d2bc899f0364b95e6	Spectrum
Predicted GC-MS	5-Isopropyl-2-methylphenol, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	splash10-0k9i-3900000000-3be7e2bf4cdcc1a3e998	Spectrum
Predicted GC-MS	5-Isopropyl-2-methylphenol, 1 TMS, Predicted GC-MS Spectrum - 70eV, Positive	splash10-0ab9-9770000000-bfcdd12ac3af31af5d4d	Spectrum
Predicted GC-MS	5-Isopropyl-2-methylphenol, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum

MS/MS

Type	Description	Splash Key	View
MS/MS	LC-MS/MS Spectrum - QTOF 3V, positive	splash10-0udi-0900000000-712524634787b6273922	Spectrum
MS/MS	LC-MS/MS Spectrum - n/a 10V, positive	splash10-0a4i-0900000000-68880fe4b40d01db1716	Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-0udi-0900000000-8a9c632983ea0192ea86	Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-0udi-2900000000-4025c9fcbf16ad5dc869	Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-0lec-9500000000-d3d61486758aa2c087bd	Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-0002-0900000000-15cb932418fd2314ac11	Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-0002-0900000000-d2de9111b421bbc52608	Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-00ls-3900000000-cae7a0406163986d258d	Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-0002-0900000000-22917433edc8ad9dbc2e	Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-0002-0900000000-ec9ac6baa6857dfd0b60	Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-05o3-7900000000-102f2168cf41515b9d4d	Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-0k96-6900000000-a06e5e505d76cfe47ff1	Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-0006-9400000000-97275967d77e94a70074	Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-004l-9100000000-623acc544c8c7c8ef29a	Spectrum

NMR

Type	Description		View
1D NMR	13C NMR Spectrum		Spectrum

External Links

ChemSpider ID

ChEMBL ID

KEGG Compound ID

Pubchem Compound ID

Pubchem Substance ID

Not Available

ChEBI ID

Not Available

Phenol-Explorer ID

672

DrugBank ID

Not Available

HMDB ID

HMDB35770

CRC / DFC (Dictionary of Food Compounds) ID

JRM60-H:JRM60-H

EAFUS ID

545

Dr. Duke ID

ISOTHYMOL|CARVACROL

BIGG ID

Not Available

KNApSAcK ID

C00000156

HET ID

Not Available

Food Biomarker Ontology

Not Available

VMH ID

Not Available

Flavornet ID

Not Available

GoodScent ID

rw1027311

SuperScent ID

Not Available

Wikipedia ID

Not Available

Phenol-Explorer Metabolite ID

Not Available

Duplicate IDS

Not Available

Old DFC IDS

Not Available

Associated Foods

Food	Content Range	Average	Reference
Food			Reference

Biological Effects and Interactions

Health Effects / Bioactivities

Descriptor	ID	Definition	Reference
allergenic	50904	A chemical compound which causes the onset of an allergic reaction by interacting with any of the molecular pathways involved in an allergy.	DUKE
anesthetic			DUKE
anti helmintic	33281	A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans.	DUKE
anti Alzheimeran	52217	Any substance introduced into a living organism with therapeutic or diagnostic purpose.	DUKE
anti atherosclerotic	38070	A drug used for the treatment or prevention of cardiac arrhythmias. Anti-arrhythmia drugs may affect the polarisation-repolarisation phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibres.	DUKE
anti bacterial	33282	A substance that kills or slows the growth of bacteria.	DUKE
anti cholinesterase	37733	An EC 3.1.1.* (carboxylic ester hydrolase) inhibitor that interferes with the action of cholinesterase (EC 3.1.1.8).	DUKE
anti diuretic	52217	Any substance introduced into a living organism with therapeutic or diagnostic purpose.	DUKE
anti inflammatory	35472	A substance that reduces or suppresses inflammation.	DUKE
anti melanomic	35610	A substance that inhibits or prevents the proliferation of neoplasms.	DUKE
antioxidant	22586	A substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides. In European countries, E-numbers for permitted antioxidant food additives are from E 300 to E 324.	DUKE
anti plaque			DUKE
anti prostaglandin	49020	A chemical substance which inhibits the function of the endocrine glands, the biosynthesis of their secreted hormones, or the action of hormones upon their specific sites.	DUKE
anti radicular			DUKE
anti septic	33281	A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans.	DUKE
anti spasmodic	52217	Any substance introduced into a living organism with therapeutic or diagnostic purpose.	DUKE
anti staphylococcic	33282	A substance that kills or slows the growth of bacteria.	DUKE
anti streptococcic	33282	A substance that kills or slows the growth of bacteria.	DUKE
anti tussive	52217	Any substance introduced into a living organism with therapeutic or diagnostic purpose.	DUKE
candidicide			DUKE
carminative			DUKE
cyclooxygenase inhibitor	35544	A compound or agent that combines with cyclooxygenases (EC 1.14.99.1) and thereby prevents its substrate-enzyme combination with arachidonic acid and the formation of icosanoids, prostaglandins, and thromboxanes.	DUKE
enterorelaxant			DUKE
expectorant	52217	Any substance introduced into a living organism with therapeutic or diagnostic purpose.	DUKE
flavor	48318	A substance, extract, or preparation for diffusing or imparting an agreeable or attractive smell.	DUKE
fungicide	24127	A substance used to destroy fungal pests.	DUKE
insectifuge	24852	Strictly, a substance intended to kill members of the class Insecta. In common usage, any substance used for preventing, destroying, repelling or controlling insects.	DUKE
irritant			DUKE
nematicide	25491	A substance used to destroy pests of the phylum Nematoda (roundworms).	DUKE
pesticide	25944	Strictly, a substance intended to kill pests. In common usage, any substance used for controlling, preventing, or destroying animal, microbiological or plant pests.	DUKE
prostaglandin inhibitor	49023	A compound that inhibits the action of prostaglandins.	DUKE
tracheorelaxant			DUKE
trichomonicide			DUKE
vermifuge	25944	Strictly, a substance intended to kill pests. In common usage, any substance used for controlling, preventing, or destroying animal, microbiological or plant pests.	DUKE

Enzymes

Not Available

Pathways

Not Available

Metabolism

Not Available

Biosynthesis

Not Available

Organoleptic Properties

Flavours

Flavor	Citations
spice	The Good Scents Company (2009). Flavor and fragrance information catalog. <http://www.thegoodscentscompany.com/allprod.html> Accessed 15.10.23.
woody	The Good Scents Company (2009). Flavor and fragrance information catalog. <http://www.thegoodscentscompany.com/allprod.html> Accessed 15.10.23.
camphor	The Good Scents Company (2009). Flavor and fragrance information catalog. <http://www.thegoodscentscompany.com/allprod.html> Accessed 15.10.23.
thymol	The Good Scents Company (2009). Flavor and fragrance information catalog. <http://www.thegoodscentscompany.com/allprod.html> Accessed 15.10.23.